For me, Twitter works best as a way of taking pictures of being stuck in traffic on the Brooklyn Bridge. If people really want to read really funny quips about life, parenting, and pop culture, then by all means read Michael Ian Black's tweets.
A lot of my humor centers on the act of telling jokes and I think this can prevent certain audiences from suspending their feeling of disbelief. It might piss a few people off, but I can't help it.