The great tragedy of science - the slaying of a beautiful hypothesis by an ugly fact.
“I protest that if some great Power would agree to make me always think what is true and do what is right, on condition of being turned into a sort of clock and would up every morning before I got out of bed, I should instantly close with the offer.”
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In scientific work, those who refuse to go beyond fact rarely get as far as fact.
The scientific imagination always restrains itself within the limits of probability.